Skip to main content

Bus from Florence, SC to San Diego, CA

More travel options

You now can select from more schedules across U.S., Mexico and Canada with Greyhound and FlixBus.

Enjoy free onboard Wi-Fi

We offer free Wi-Fi and power outlets to keep you connected and powered up during your trip.

Reserve a Seat

Reserve your favorite seat when you book your ticket.

Need to make a change?

Easily change your ticket or add bags with Manage My Booking.

What to expect of your trip

Fast, easy, and affordable options from Florence, SC to San Diego, CA

On this page

Bus stations and stops in Florence, SC

Please note: your ticket will contain the most up-to-date address information.
Best service on board
Available options you can find for a more comfortable trip:
wifi
Free WiFi
Stay connected throughout your journey
socket
Power Outlets
Keep your devices charged on the go
seat
Comfortable seats
Relax with extra legroom and reclining seats
luggage
Luggage storage
Space to safely stow your belongings
toilet
Toilets
Conveniently available on every FlixBus
First time travelling with us?
More on our service
Amenities Hero Image
Where to next?
Discover our travel map with over 1600 destinations across the U.S., Canada and Mexico.
Explore the map
Vehicle passing through a city

Frequently asked questions

Yes, on this website you can book both Greyhound and FlixBus tickets from Florence to San Diego. You can check both the Greyhound and FlixBus ride schedules once you select your departure city, destination city, and desired trip date.
The bus trip from Florence to San Diego is about 2753 miles long. The quickest trip with Greyhound takes 60 hours.
Greyhound runs up to 3 rides per day from Florence to San Diego. You can search for your preferred departure date and check the schedule using the search bar above.
You can track the status of your Florence to San Diego bus using Greyhound's bus tracker. With this tool, you can see the real-time location of your bus and get updates on its departure and arrival times.
Onboard services available on Greyhound buses from Florence to San Diego include free Wi-Fi for all passengers, personal power outlets near every seat, reclining leather seats with footrests, extra legroom, overhead storage, and an on-board restroom.
The first Greyhound bus to San Diego from Florence leaves at 12:05 am.
The last Greyhound bus to San Diego from Florence leaves at 4:30 pm.
When traveling on the bus from Florence to San Diego with Greyhound, you can bring one carry-on bag with you (maximum 25 lbs, 16x12x7 inches). You can store one bag under the bus for free, and if you have a Flexible fare, the second bag stored under the bus is also free. You can also carry additional or bulky baggage for a supplementary charge. You can reserve extra baggage while booking your ticket on our website or app. Alternatively, you can add bulky items later through the 'Manage My Booking' section. If your departure is from a location with Greyhound personnel, you can book and pay for your extra luggage there. For more information, please refer to our baggage policy page here.
Greyhound buses are equipped with wheelchair lifts to assist passengers using wheelchairs or mobility scooters. Each bus has space for two passengers with these devices. It's recommended to book your bus from Florence to San Diego in advance to ensure a spot. If you'd like to transfer to a regular seat, our drivers will stow your device for you. Service animals are also welcome on board our buses. For further details on accessibility and service animal policies, please check this link.
Traveling by bus from Florence to San Diego with Greyhound is a convenient and environmentally responsible choice, as bus travel reduces traffic and emissions compared to traveling by car.
You can easily find the locations and addresses of the bus stops in Florence and in San Diego on this page: check the address and their location on the map!
  • Florence has 2 bus stop(s), namely: Florence (SC), Florence Bus Station
  • San Diego has 4 bus stop(s), namely: San Diego (Downtown/Seaport Village), San Diego (La Jolla - UC San Diego), San Diego (Old Town-FlixBus), San Diego Greyhound Bus Stop

Plan your bus trip from Florence to San Diego with Greyhound

The first bus departs at 12:05 am and the last bus departs at 4:30 pm. Greyhound operates 3 bus rides daily between Florence and San Diego. When traveling with Greyhound to San Diego from Florence, expect free Wifi, power sockets, and a guaranteed seat for your journey. Don't miss any updates on your bus trip: stay informed with our real-time bus tracker and check the status of your ride to San Diego in seconds.

How to Book Your Bus Ticket to San Diego from Florence

With Greyhound, reserving a ticket for your bus trip is a breeze. You can easily complete your booking on this website or through the free Greyhound App, all within a few simple clicks. You will have a variety of rides to choose from, as on many of our routes you will be offered both Greyhound and FlixBus bus rides, so you can choose the option that best fits your schedule. When booking your ticket from Florence to San Diego, you have a range of secure online payment options at your disposal, including both debit and credit cards. If you prefer, cash payments are also accepted at various sales points. If you're on the hunt for a cheap ticket to San Diego, remember to book early. Traveling on weekdays or during non-peak hours can also lead you to some of the most budget-friendly fares available!

Onboard services are subject to availability