Skip to main content

Bus from Orange County-Anaheim-Santa Ana, CA to Chicago, IL

More travel options

You now can select from more schedules across U.S., Mexico and Canada with Greyhound and FlixBus.
Explore now

Enjoy free onboard entertainment

Watch a FREE movie and use our power outlets to stay powered up during your trip.
Find out what’s playing

Reserve a Seat

Reserve your favorite seat when you book your ticket.
Window or Aisle?

Need to make a change?

Easily change your ticket or add bags with Manage My Booking.
Discover all your options

On this page

Bus stations and stops in Orange County-Anaheim-Santa Ana, CA

Please note: your ticket will contain the most up-to-date address information.

Discover all the places you can go

Choose from almost 2,300 destinations with Greyhound, FlixBus and our connecting partners!

Frequently asked questions

The first Greyhound bus from Orange County-Anaheim-Santa Ana to Chicago departs at 10:05 am.
Onboard amenities on Greyhound buses from Orange County-Anaheim-Santa Ana to Chicago include free Wi-Fi, personal power outlets, reclining seats with extra legroom, overhead storage, and an onboard restroom.
Opting for Greyhound to travel from Orange County-Anaheim-Santa Ana to Chicago is an environmentally responsible choice, reducing traffic and lowering emissions compared to car travel.
When traveling from Orange County-Anaheim-Santa Ana to Chicago with Greyhound, you can bring one carry-on bag (up to 25 lbs, 16x12x7 inches) for free. Additionally, one checked bag is included, with a second bag free for Flexible fare passengers. Extra or oversized baggage can be added during booking or later through the "Manage My Booking" section. Some locations also allow in-person payment for additional luggage. Full details are available on our baggage policy page.
To track your bus from Orange County-Anaheim-Santa Ana to Chicago, use Greyhound’s bus tracker. This tool provides live updates on the bus’s location and expected arrival times.
Bus tickets from Orange County-Anaheim-Santa Ana to Chicago start at $280.99. For the best rates, it is recommended to book in advance via our app or website. You can pay online using debit or credit cards, or choose to pay in person with cash at selected locations.
The journey by Greyhound bus from Orange County-Anaheim-Santa Ana to Chicago covers approximately 2163 miles. The quickest trip duration is 47 hours 5 minutes, .
The last Greyhound bus from Orange County-Anaheim-Santa Ana to Chicago leaves at 9:40 pm.
You can find the Greyhound bus stops in both Orange County-Anaheim-Santa Ana and Chicago by checking the map on this page, which shows the addresses and locations of all stops.
Greyhound buses are equipped with wheelchair lifts and have space for two passengers using wheelchairs or mobility scooters. We recommend booking your trip from Orange County-Anaheim-Santa Ana to Chicago in advance to secure the necessary accommodations. Service animals are also welcome on all Greyhound buses. For more details, visit our accessibility page.
Greyhound operates up to 2 trips daily from Orange County-Anaheim-Santa Ana to Chicago. You can find the schedule by entering your departure date in the search box above.
Yes, you can book both Greyhound and FlixBus tickets for travel from Orange County-Anaheim-Santa Ana to Chicago through our website. After selecting your cities and travel dates, you can compare the schedules and prices of both services.

Planning Your Greyhound Bus Trip from Orange County-Anaheim-Santa Ana to Chicago?

The journey from Orange County-Anaheim-Santa Ana to Chicago can take as little as 47 hours 5 minutes and starts from as little as $280.99. The earliest bus leaves at 10:05 am and the last bus leaves at 9:40 pm. Greyhound schedules 2 buses per day from Orange County-Anaheim-Santa Ana to Chicago. Travel with Greyhound and enjoy complimentary Wifi, access to power sockets, and a comfortable seat throughout your trip. Don't miss any updates on your bus trip: stay informed with our real-time bus tracker and check the status of your ride to Chicago in seconds.

How to Book Your Bus Ticket to Chicago from Orange County-Anaheim-Santa Ana

With Greyhound, reserving a ticket for your bus trip is a breeze. You can easily complete your booking on this website or through the free Greyhound App, all within a few simple clicks. You will have a variety of rides to choose from, as on many of our routes you will be offered both Greyhound and FlixBus bus rides, so you can choose the option that best fits your schedule. When booking your ticket from Orange County-Anaheim-Santa Ana to Chicago, you have a range of secure online payment options at your disposal, including both debit and credit cards. If you prefer, cash payments are also accepted at various sales points. If you're on the hunt for a cheap ticket to Chicago, remember to book early. Traveling on weekdays or during non-peak hours can also lead you to some of the most budget-friendly fares available!

Onboard services are subject to availability