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Bus from Key West, FL to San Francisco, CA

More travel options

You now can select from more schedules across U.S., Mexico and Canada with Greyhound and FlixBus.

Enjoy free onboard Wi-Fi

We offer free Wi-Fi and power outlets to keep you connected and powered up during your trip.

Reserve a Seat

Reserve your favorite seat when you book your ticket.

Need to make a change?

Easily change your ticket or add bags with Manage My Booking.

What to expect of your trip

Fast, easy, and affordable options from Key West, FL to San Francisco, CA

Avg. trip duration

85 hr 10 mins

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Avg. distance

3572 miles

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Cheapest trip

From $349.43

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2

Avg. trips a day

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On this page

Bus stations and stops in Key West, FL

Please note: your ticket will contain the most up-to-date address information.
Best service on board
Available options you can find for a more comfortable trip:
wifi
Free WiFi
Stay connected throughout your journey
socket
Power Outlets
Keep your devices charged on the go
seat
Comfortable seats
Relax with extra legroom and reclining seats
luggage
Luggage storage
Space to safely stow your belongings
toilet
Toilets
Conveniently available on every FlixBus
First time travelling with us?
More on our service
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Onboard services are subject to availability

Where to next?
Discover our travel map with over 1600 destinations across the U.S., Canada and Mexico.
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Frequently asked questions

The journey by Greyhound bus from Key West to San Francisco covers approximately 3575 miles. The quickest trip takes 80 hours 5 minutes.
Bus tickets from Key West to San Francisco start at $349.43. For the best rates, it is recommended to book in advance via our app or website. You can pay online using debit or credit cards, or choose to pay in person with cash at selected locations.
To track your bus from Key West to San Francisco, use Greyhound’s bus tracker. This tool provides live updates on the bus’s location and expected arrival times.
When traveling from Key West to San Francisco with Greyhound, you can bring one carry-on bag (up to 25 lbs, 16x12x7 inches) for free. Additionally, one checked bag is included, with a second bag free for Flexible fare passengers. Extra or oversized baggage can be added during booking or later through the "Manage My Booking" section. Some locations also allow in-person payment for additional luggage. Full details are available on our baggage policy page.
Opting for Greyhound to travel from Key West to San Francisco is an environmentally responsible choice, reducing traffic and lowering emissions compared to car travel.
Onboard amenities on Greyhound buses from Key West to San Francisco include free Wi-Fi, personal power outlets, reclining seats with extra legroom, overhead storage, and an onboard restroom.
The first Greyhound bus from Key West to San Francisco departs at 10:00 am.
The last Greyhound bus from Key West to San Francisco leaves at 5:00 pm.
Yes, you can book both Greyhound and FlixBus tickets for travel from Key West to San Francisco through our website. After selecting your cities and travel dates, you can compare the schedules and prices of both services.
Greyhound operates up to 3 trips daily from Key West to San Francisco. You can find the schedule by entering your departure date in the search box above.
Greyhound buses are equipped with wheelchair lifts and have space for two passengers using wheelchairs or mobility scooters. We recommend booking your trip from Key West to San Francisco in advance to secure the necessary accommodations. Service animals are also welcome on all Greyhound buses. For more details, visit our accessibility page.
You can find the Greyhound bus stops in both Key West and San Francisco by checking the map on this page, which shows the addresses and locations of all stops.

Planning Your Greyhound Bus Trip from Key West to San Francisco?

The journey from Key West to San Francisco can take as little as 80 hours 5 minutes and starts from as little as $349.43. The earliest bus leaves at 10:00 am and the last bus leaves at 5:00 pm. Greyhound schedules 3 buses per day from Key West to San Francisco. Travel with Greyhound and enjoy complimentary Wifi, access to power sockets, and a comfortable seat throughout your trip. Don't miss any updates on your bus trip: stay informed with our real-time bus tracker and check the status of your ride to San Francisco in seconds.

How to Book Your Bus Ticket to San Francisco from Key West

With Greyhound, reserving a ticket for your bus trip is a breeze. You can easily complete your booking on this website or through the free Greyhound App, all within a few simple clicks. You will have a variety of rides to choose from, as on many of our routes you will be offered both Greyhound and FlixBus bus rides, so you can choose the option that best fits your schedule. When booking your ticket from Key West to San Francisco, you have a range of secure online payment options at your disposal, including both debit and credit cards. If you prefer, cash payments are also accepted at various sales points. If you're on the hunt for a cheap ticket to San Francisco, remember to book early. Traveling on weekdays or during non-peak hours can also lead you to some of the most budget-friendly fares available!
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