Bus from Port St. Lucie, FL to Key West, FL

More travel options

You now can select from more schedules across U.S., Mexico and Canada with Greyhound and FlixBus.

Enjoy free onboard Wi-Fi

We offer free Wi-Fi and power outlets to keep you connected and powered up during your trip.

Reserve a Seat

Reserve your favorite seat when you book your ticket.

Need to make a change?

Easily change your ticket or add bags with Manage My Booking.

What to expect of your trip

Fast, easy, and affordable options from Port St. Lucie, FL to Key West, FL

Safe Payment

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Easy to buy

Get your tickets online, in our App, or in a Flixshop

Customer care

Effortless support from booking to travel

Bus stations and stops in Port St. Lucie, FL

Please note: your ticket will contain the most up-to-date address information.

Port St Lucie (Park & Ride)

2198 Sw Gatlin Blvd
Port St. Lucie, FL 34953
United States

View this address on Google Maps

To view more info about this station, visit our page Port St Lucie (Park & Ride)

Best service on board

Available options you can find for a more comfortable trip:

Free WiFi

Stay connected throughout your journey

Power Outlets

Keep your devices charged on the go

Comfortable seats

Relax with extra legroom and reclining seats

Luggage storage

Space to safely stow your belongings

Toilets

Conveniently available on every FlixBus

First time travelling with us?

Frequently asked questions

How many daily Greyhound bus trips are there from Port St. Lucie to Key West?

There are up to one Greyhound bus operating daily from Port St. Lucie to Key West. Check the schedule by entering your travel date in the search box above.

What facilities does Greyhound provide for passengers with reduced mobility and service animals?

Greyhound offers wheelchair lifts and space for passengers using mobility devices. It is recommended to book your trip from Port St. Lucie to Key West in advance. Service animals are welcome on all Greyhound buses. For more information, visit our accessibility page.

Where are the Greyhound bus stops in Port St. Lucie and in Key West?

The locations of Greyhound bus stops in Port St. Lucie and Key West can be found on this page, along with detailed maps and addresses.

Can I book bus tickets both for Greyhound and FlixBus to travel from Port St. Lucie to Key West?

Yes, you can book both Greyhound and FlixBus tickets for travel from Port St. Lucie to Key West on our website. Simply enter your travel details to compare schedules and fares.

How long does the bus from Port St. Lucie to Key West take with Greyhound?

The travel time from Port St. Lucie to Key West by bus is approximately 12 hours 10 minutes, covering a distance of about 293 miles.

How do I track my Greyhound bus from Port St. Lucie to Key West ?

You can check the status of your Greyhound bus traveling from Port St. Lucie to Key West by using our bus tracker. This tool provides real-time updates on your bus’s location and expected arrival time.

How much baggage can I bring on the bus from Port St. Lucie to Key West?

For your trip from Port St. Lucie to Key West, Greyhound allows one carry-on bag (max 25 lbs, 16x12x7 inches) and one checked bag under the bus at no extra charge. A second checked bag is free with a Flexible fare. You can add extra baggage during booking or later via "Manage My Booking," or at certain locations. Full details are on our baggage policy page.

Is traveling with Greyhound from Port St. Lucie to Key West environmentally-friendly?

Traveling by Greyhound from Port St. Lucie to Key West is an environmentally friendly option, helping to reduce carbon emissions and traffic congestion compared to car travel.

What onboard services are available on Greyhound buses from Port St. Lucie to Key West?

On Greyhound buses from Port St. Lucie to Key West, you can enjoy free Wi-Fi, power outlets at each seat, comfortable reclining seats with extra legroom, overhead storage, and access to an onboard restroom.

What time is the first bus from Port St. Lucie to Key West?

The earliest bus from Port St. Lucie to Key West departs at 3:20 am.

What time is the last bus from Port St. Lucie to Key West?

The latest bus from Port St. Lucie to Key West leaves at 3:20 am.

Looking for Greyhound Bus Tickets from Port St. Lucie to Key West?

How to Book Your Bus Trip to Key West from Port St. Lucie

With Greyhound, reserving a ticket for your bus trip is a breeze. You can easily complete your booking on this website or through the free Greyhound App, all within a few simple clicks. You will have a variety of rides to choose from, as on many of our routes you will be offered both Greyhound and FlixBus bus rides, so you can choose the option that best fits your schedule. When booking your ticket from Port St. Lucie to Key West, you have a range of secure online payment options at your disposal, including both debit and credit cards. If you prefer, cash payments are also accepted at various sales points. If you're on the hunt for a cheap ticket to Key West, remember to book early. Traveling on weekdays or during non-peak hours can also lead you to some of the most budget-friendly fares available!

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Onboard services are subject to availability