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Bus from Orlando, FL to Florence, SC

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Bus stations and stops in Orlando, FL

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Frequently asked questions

The first Greyhound bus from Orlando to Florence departs at 4:45 am.
Onboard amenities on Greyhound buses from Orlando to Florence include free Wi-Fi, personal power outlets, reclining seats with extra legroom, overhead storage, and an onboard restroom.
Opting for Greyhound to travel from Orlando to Florence is an environmentally responsible choice, reducing traffic and lowering emissions compared to car travel.
When traveling from Orlando to Florence with Greyhound, you can bring one carry-on bag (up to 25 lbs, 16x12x7 inches) for free. Additionally, one checked bag is included, with a second bag free for Flexible fare passengers. Extra or oversized baggage can be added during booking or later through the "Manage My Booking" section. Some locations also allow in-person payment for additional luggage. Full details are available on our baggage policy page.
To track your bus from Orlando to Florence, use Greyhound’s bus tracker. This tool provides live updates on the bus’s location and expected arrival times.
Bus tickets from Orlando to Florence start at $59.99. For the best rates, it is recommended to book in advance via our app or website. You can pay online using debit or credit cards, or choose to pay in person with cash at selected locations.
The journey by Greyhound bus from Orlando to Florence covers approximately 463 miles. The quickest trip duration is 8 hours 19 minutes, with at least 5 stops.
The last Greyhound bus from Orlando to Florence leaves at 9:00 pm.
You can find the Greyhound bus stops in both Orlando and Florence by checking the map on this page, which shows the addresses and locations of all stops.
Greyhound buses are equipped with wheelchair lifts and have space for two passengers using wheelchairs or mobility scooters. We recommend booking your trip from Orlando to Florence in advance to secure the necessary accommodations. Service animals are also welcome on all Greyhound buses. For more details, visit our accessibility page.
Greyhound operates up to 1 trip daily from Orlando to Florence. You can find the schedule by entering your departure date in the search box above.
Yes, you can book both Greyhound and FlixBus tickets for travel from Orlando to Florence through our website. After selecting your cities and travel dates, you can compare the schedules and prices of both services.

Planning Your Greyhound Bus Trip from Orlando to Florence?

The journey from Orlando to Florence can take as little as 8 hours 19 minutes and starts from as little as $59.99. The earliest bus leaves at 4:45 am and the last bus leaves at 9:00 pm. Greyhound provides daily buses Orlando to Florence from Orlando to Florence. Travel with Greyhound and enjoy complimentary Wifi, access to power sockets, and a comfortable seat throughout your trip. Don't miss any updates on your bus trip: stay informed with our real-time bus tracker and check the status of your ride to Florence in seconds.

How to Book Your Bus Ticket to Florence from Orlando

With Greyhound, reserving a ticket for your bus trip is a breeze. You can easily complete your booking on this website or through the free Greyhound App, all within a few simple clicks. You will have a variety of rides to choose from, as on many of our routes you will be offered both Greyhound and FlixBus bus rides, so you can choose the option that best fits your schedule. When booking your ticket from Orlando to Florence, you have a range of secure online payment options at your disposal, including both debit and credit cards. If you prefer, cash payments are also accepted at various sales points. If you're on the hunt for a cheap ticket to Florence, remember to book early. Traveling on weekdays or during non-peak hours can also lead you to some of the most budget-friendly fares available!

Onboard services are subject to availability