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Bus from Knoxville, TN to Buffalo, NY

More travel options

You now can select from more schedules across U.S., Mexico and Canada with Greyhound and FlixBus.

Enjoy free onboard Wi-Fi

We offer free Wi-Fi and power outlets to keep you connected and powered up during your trip.

Reserve a Seat

Reserve your favorite seat when you book your ticket.

Need to make a change?

Easily change your ticket or add bags with Manage My Booking.

What to expect of your trip

Fast, easy, and affordable options from Knoxville, TN to Buffalo, NY

Avg. trip duration

23hr39mins

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Avg. distance

949 miles

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Cheapest trip

From $105.46

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2

Avg. trips a day

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On this page

Bus stations and stops in Knoxville, TN

Please note: your ticket will contain the most up-to-date address information.
Best service on board
Available options you can find for a more comfortable trip:
wifi
Free WiFi
Stay connected throughout your journey
socket
Power Outlets
Keep your devices charged on the go
seat
Comfortable seats
Relax with extra legroom and reclining seats
luggage
Luggage storage
Space to safely stow your belongings
toilet
Toilets
Conveniently available on every FlixBus
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More on our service
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Where to next?
Discover our travel map with over 1600 destinations across the U.S., Canada and Mexico.
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Frequently asked questions

The journey by Greyhound bus from Knoxville to Buffalo covers approximately 759 miles. The quickest trip takes 18 hours 15 minutes.
Bus tickets from Knoxville to Buffalo start at $105.46. For the best rates, it is recommended to book in advance via our app or website. You can pay online using debit or credit cards, or choose to pay in person with cash at selected locations.
To track your bus from Knoxville to Buffalo, use Greyhound’s bus tracker. This tool provides live updates on the bus’s location and expected arrival times.
When traveling from Knoxville to Buffalo with Greyhound, you can bring one carry-on bag (up to 25 lbs, 16x12x7 inches) for free. Additionally, one checked bag is included, with a second bag free for Flexible fare passengers. Extra or oversized baggage can be added during booking or later through the "Manage My Booking" section. Some locations also allow in-person payment for additional luggage. Full details are available on our baggage policy page.
Opting for Greyhound to travel from Knoxville to Buffalo is an environmentally responsible choice, reducing traffic and lowering emissions compared to car travel.
Onboard amenities on Greyhound buses from Knoxville to Buffalo include free Wi-Fi, personal power outlets, reclining seats with extra legroom, overhead storage, and an onboard restroom.
The first Greyhound bus from Knoxville to Buffalo departs at 10:00 pm.
The last Greyhound bus from Knoxville to Buffalo leaves at 10:50 pm.
Yes, you can book both Greyhound and FlixBus tickets for travel from Knoxville to Buffalo through our website. After selecting your cities and travel dates, you can compare the schedules and prices of both services.
Greyhound operates up to 2 trips daily from Knoxville to Buffalo. You can find the schedule by entering your departure date in the search box above.
Greyhound buses are equipped with wheelchair lifts and have space for two passengers using wheelchairs or mobility scooters. We recommend booking your trip from Knoxville to Buffalo in advance to secure the necessary accommodations. Service animals are also welcome on all Greyhound buses. For more details, visit our accessibility page.
You can find the Greyhound bus stops in both Knoxville and Buffalo by checking the map on this page, which shows the addresses and locations of all stops.

Planning Your Greyhound Bus Trip from Knoxville to Buffalo?

The journey from Knoxville to Buffalo can take as little as 18 hours 15 minutes and starts from as little as $105.46. The earliest bus leaves at 10:00 pm and the last bus leaves at 10:50 pm. Greyhound schedules 2 buses per day from Knoxville to Buffalo. Travel with Greyhound and enjoy complimentary Wifi, access to power sockets, and a comfortable seat throughout your trip. Don't miss any updates on your bus trip: stay informed with our real-time bus tracker and check the status of your ride to Buffalo in seconds.

How to Book Your Bus Ticket to Buffalo from Knoxville

With Greyhound, reserving a ticket for your bus trip is a breeze. You can easily complete your booking on this website or through the free Greyhound App, all within a few simple clicks. You will have a variety of rides to choose from, as on many of our routes you will be offered both Greyhound and FlixBus bus rides, so you can choose the option that best fits your schedule. When booking your ticket from Knoxville to Buffalo, you have a range of secure online payment options at your disposal, including both debit and credit cards. If you prefer, cash payments are also accepted at various sales points. If you're on the hunt for a cheap ticket to Buffalo, remember to book early. Traveling on weekdays or during non-peak hours can also lead you to some of the most budget-friendly fares available!
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Onboard services are subject to availability