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Bus from Greenville, SC to Clarksdale, MS

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Bus stations and stops in Greenville, SC

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Frequently asked questions

The first Greyhound bus from Greenville to Clarksdale departs at 11:20 am.
Onboard amenities on Greyhound buses from Greenville to Clarksdale include free Wi-Fi, personal power outlets, reclining seats with extra legroom, overhead storage, and an onboard restroom.
Opting for Greyhound to travel from Greenville to Clarksdale is an environmentally responsible choice, reducing traffic and lowering emissions compared to car travel.
When traveling from Greenville to Clarksdale with Greyhound, you can bring one carry-on bag (up to 25 lbs, 16x12x7 inches) for free. Additionally, one checked bag is included, with a second bag free for Flexible fare passengers. Extra or oversized baggage can be added during booking or later through the "Manage My Booking" section. Some locations also allow in-person payment for additional luggage. Full details are available on our baggage policy page.
To track your bus from Greenville to Clarksdale, use Greyhound’s bus tracker. This tool provides live updates on the bus’s location and expected arrival times.
The journey by Greyhound bus from Greenville to Clarksdale covers approximately 692 miles. The quickest trip duration is 18 hours 55 minutes, .
The last Greyhound bus from Greenville to Clarksdale leaves at 3:30 pm.
You can find the Greyhound bus stops in both Greenville and Clarksdale by checking the map on this page, which shows the addresses and locations of all stops.
Greyhound buses are equipped with wheelchair lifts and have space for two passengers using wheelchairs or mobility scooters. We recommend booking your trip from Greenville to Clarksdale in advance to secure the necessary accommodations. Service animals are also welcome on all Greyhound buses. For more details, visit our accessibility page.
Greyhound operates up to 2 trips daily from Greenville to Clarksdale. You can find the schedule by entering your departure date in the search box above.
Yes, you can book both Greyhound and FlixBus tickets for travel from Greenville to Clarksdale through our website. After selecting your cities and travel dates, you can compare the schedules and prices of both services.

Planning Your Greyhound Bus Trip from Greenville to Clarksdale?

How to Book Your Bus Ticket to Clarksdale from Greenville

With Greyhound, reserving a ticket for your bus trip is a breeze. You can easily complete your booking on this website or through the free Greyhound App, all within a few simple clicks. You will have a variety of rides to choose from, as on many of our routes you will be offered both Greyhound and FlixBus bus rides, so you can choose the option that best fits your schedule. When booking your ticket from Greenville to Clarksdale, you have a range of secure online payment options at your disposal, including both debit and credit cards. If you prefer, cash payments are also accepted at various sales points. If you're on the hunt for a cheap ticket to Clarksdale, remember to book early. Traveling on weekdays or during non-peak hours can also lead you to some of the most budget-friendly fares available!

Onboard services are subject to availability