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Bus from Columbia, SC to Key West, FL
More travel options
You now can select from more schedules across U.S., Mexico and Canada with Greyhound and FlixBus.
Enjoy free onboard Wi-Fi
We offer free Wi-Fi and power outlets to keep you connected and powered up during your trip.
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Bus stations and stops in Columbia, SC
Discover more popular bus connections
- Columbia, SC - Atlanta, GA
- Charlotte, NC - Columbia, SC
- Atlanta, GA - Columbia, SC
- Columbia, SC - Charlotte, NC
- North Charleston, SC - Columbia, SC
- Columbia, SC - North Charleston, SC
- Myrtle Beach, SC - Columbia, SC
- Columbia, SC - Myrtle Beach, SC
- Savannah, GA - Columbia, SC
- Florence, SC - Columbia, SC
- Columbia, SC - New York, NY
- Raleigh, NC - Columbia, SC
- Columbia, SC - Washington, D.C.
- Columbia, SC - Savannah, GA
- Orangeburg, SC - Columbia, SC
- Columbia, SC - Florence, SC
- Greensboro, NC - Columbia, SC
- Fayetteville, NC - Columbia, SC
- Columbia, SC - Fayetteville, NC
- Birmingham, AL - Columbia, SC
- Key West, FL - Miami, FL
- Miami, FL - Key West, FL
- Fort Lauderdale, FL - Key West, FL
- Marathon, FL - Key West, FL
- Key West, FL - Key Largo, FL
- Key West, FL - Marathon, FL
- Key West, FL - Islamorada, FL
- Key Largo, FL - Key West, FL
- Key West, FL - Dallas, TX
- Islamorada, FL - Key West, FL
- Pueblo, CO - Key West, FL
- Boston, MA - Key West, FL
- Key West, FL - Orangeburg, SC
- Atlanta, GA - Key West, FL
- Austin, TX - Key West, FL
- Key West, FL - Mobile, AL
- Key West, FL - Providence, RI
- Indianapolis, IN - Key West, FL
- Key West, FL - Daytona Beach, FL
- Columbia, SC - Key West, FL
Onboard services are subject to availability