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Bus from Cape Girardeau, MO to Tampa, FL

More travel options

You now can select from more schedules across U.S., Mexico and Canada with Greyhound and FlixBus.

Enjoy free onboard Wi-Fi

We offer free Wi-Fi and power outlets to keep you connected and powered up during your trip.

Reserve a Seat

Reserve your favorite seat when you book your ticket.

Need to make a change?

Easily change your ticket or add bags with Manage My Booking.

What to expect of your trip

Fast, easy, and affordable options from Cape Girardeau, MO to Tampa, FL

Min. trip duration

25 hr 15 mins

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Min. distance

1092 miles

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Cheapest trip

From $144.95

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2

Min. trips a day

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FlixBus app on phone

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On this page

Bus stations and stops in Cape Girardeau, MO

Please note: your ticket will contain the most up-to-date address information.
Best service on board
Available options you can find for a more comfortable trip:
wifi
Free WiFi
Stay connected throughout your journey
socket
Power Outlets
Keep your devices charged on the go
seat
Comfortable seats
Relax with extra legroom and reclining seats
luggage
Luggage storage
Space to safely stow your belongings
toilet
Toilets
Conveniently available on every FlixBus
First time travelling with us?
More on our service
Amenities Hero Image

Onboard services are subject to availability

Where to next?
Discover our travel map with over 1600 destinations across the U.S., Canada and Mexico.
Explore the map
Vehicle passing through a city

Digital ticket & Live tracking

Discover the Greyhound app

Book trips
Your tickets
Track your trip
Always in the know
Get it on Google Play Download on the App Store
FlixBus app on phone

Scan to download the App

Trusted by 500+ million passengers

Frequently asked questions

Greyhound buses from Cape Girardeau to Tampa offer free Wi-Fi, power outlets at each seat, reclining seats with extra legroom, overhead storage, and onboard restrooms.
Choosing Greyhound for your journey from Cape Girardeau to Tampa is an eco-conscious option, helping to reduce emissions and traffic compared to traveling by car.
On the Greyhound bus from Cape Girardeau to Tampa, you can bring one carry-on bag (16x12x7 in, up to 25 lbs) and one checked bag at no extra cost. With a Flexible fare, a second checked bag is also free. Need more? Add extra luggage when you book. For full details, check our baggage policy.
To track your Greyhound bus from Cape Girardeau to Tampa, use our bus tracker. It provides real-time updates on your bus’s location and expected arrival times.
Greyhound bus tickets from Cape Girardeau to Tampa start from $144.95. For the best fares, book early or choose midweek departures.
The fastest Greyhound bus from Cape Girardeau to Tampa takes around 25 hours 15 minutes and covers approximately 1098 miles. Actual travel time may vary depending on traffic and the route.
The first bus from Cape Girardeau to Tampa departs at 03:15 am.
You can pay for your Greyhound bus ticket from Cape Girardeau to Tampa by card, digital wallet, and other methods. All available payment options are shown at checkout. For more details, check our payments and tickets page.
No need to print your ticket. Just show the QR code from your confirmation email or the Greyhound app to the driver when you board your bus from Cape Girardeau to Tampa.
You can find the bus stops for Greyhound in both Cape Girardeau and Tampa by viewing the map on this page, which includes addresses and locations of all stops.
Greyhound buses are equipped with wheelchair lifts and spaces for passengers using mobility devices. We recommend booking your trip from Cape Girardeau to Tampa in advance. Service animals are welcome on all Greyhound buses. For more information, please visit our accessibility page.
Greyhound operates 2 daily departures from Cape Girardeau to Tampa. Check available times for your dates on the website or app.
Yes, you can book tickets for both Greyhound and FlixBus from Cape Girardeau to Tampa on our website. After entering your travel details, you can compare schedules and fares for both options.
The last bus from Cape Girardeau to Tampa departs at 09:10 pm.

Plan your bus trip from Cape Girardeau to Tampa with Greyhound

The trip from Cape Girardeau to Tampa takes as short as 25 hours 15 minutes and could cost as little as $144.95. The first bus departs at 03:15 am and the last bus departs at 09:10 pm. Greyhound operates 2 bus rides daily between Cape Girardeau and Tampa. When traveling with Greyhound to Tampa from Cape Girardeau, expect free Wifi, power sockets, and a guaranteed seat for your journey. Don't miss any updates on your bus trip: stay informed with our real-time bus tracker and check the status of your ride to Tampa in seconds.

How to Book Your Bus Ticket to Tampa from Cape Girardeau

With Greyhound, reserving a ticket for your bus trip is a breeze. You can easily complete your booking on this website or through the free Greyhound App, all within a few simple clicks. You will have a variety of rides to choose from, as on many of our routes you will be offered both Greyhound and FlixBus bus rides, so you can choose the option that best fits your schedule. When booking your ticket from Cape Girardeau to Tampa, you have a range of secure online payment options at your disposal, including both debit and credit cards. If you prefer, cash payments are also accepted at various sales points. If you're on the hunt for a cheap ticket to Tampa, remember to book early. Traveling on weekdays or during non-peak hours can also lead you to some of the most budget-friendly fares available!