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Bus from Wytheville, VA to Cape Girardeau, MO

More travel options

You now can select from more schedules across U.S., Mexico and Canada with Greyhound and FlixBus.

Enjoy free onboard Wi-Fi

We offer free Wi-Fi and power outlets to keep you connected and powered up during your trip.

Reserve a Seat

Reserve your favorite seat when you book your ticket.

Need to make a change?

Easily change your ticket or add bags with Manage My Booking.

What to expect of your trip

Fast, easy, and affordable options from Wytheville, VA to Cape Girardeau, MO

Min. trip duration

21 hr 50 mins

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Min. distance

897 miles

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Cheapest trip

From $99.96

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3

Min. trips a day

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On this page

Bus stations and stops in Wytheville, VA

Please note: your ticket will contain the most up-to-date address information.
Best service on board
Available options you can find for a more comfortable trip:
wifi
Free WiFi
Stay connected throughout your journey
socket
Power Outlets
Keep your devices charged on the go
seat
Comfortable seats
Relax with extra legroom and reclining seats
luggage
Luggage storage
Space to safely stow your belongings
toilet
Toilets
Conveniently available on every FlixBus
First time travelling with us?
More on our service
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Onboard services are subject to availability

Where to next?
Discover our travel map with over 1600 destinations across the U.S., Canada and Mexico.
Explore the map
Vehicle passing through a city

Digital ticket & Live tracking

Discover the Greyhound app

Book trips
Your tickets
Track your trip
Always in the know
Get it on Google Play Download on the App Store
FlixBus app on phone

Scan to download the App

Trusted by 500+ million passengers

Frequently asked questions

The fastest Greyhound bus from Wytheville to Cape Girardeau takes around 21 hours 50 minutes and covers approximately 902 miles. Actual travel time may vary depending on traffic and the route.
Greyhound bus tickets from Wytheville to Cape Girardeau start from $99.96. For the best fares, book early or choose midweek departures.
To track your Greyhound bus from Wytheville to Cape Girardeau, use our bus tracker. It provides real-time updates on your bus’s location and expected arrival times.
On the Greyhound bus from Wytheville to Cape Girardeau, you can bring one carry-on bag (16x12x7 in, up to 25 lbs) and one checked bag at no extra cost. With a Flexible fare, a second checked bag is also free. Need more? Add extra luggage when you book. For full details, check our baggage policy.
Choosing Greyhound for your journey from Wytheville to Cape Girardeau is an eco-conscious option, helping to reduce emissions and traffic compared to traveling by car.
Greyhound buses from Wytheville to Cape Girardeau offer free Wi-Fi, power outlets at each seat, reclining seats with extra legroom, overhead storage, and onboard restrooms.
The first bus from Wytheville to Cape Girardeau departs at 02:15 am.
The last bus from Wytheville to Cape Girardeau departs at 02:30 pm.
Yes, you can book tickets for both Greyhound and FlixBus from Wytheville to Cape Girardeau on our website. After entering your travel details, you can compare schedules and fares for both options.
Greyhound operates 3 daily departures from Wytheville to Cape Girardeau. Check available times for your dates on the website or app.
Greyhound buses are equipped with wheelchair lifts and spaces for passengers using mobility devices. We recommend booking your trip from Wytheville to Cape Girardeau in advance. Service animals are welcome on all Greyhound buses. For more information, please visit our accessibility page.
You can find the bus stops for Greyhound in both Wytheville and Cape Girardeau by viewing the map on this page, which includes addresses and locations of all stops.
No need to print your ticket. Just show the QR code from your confirmation email or the Greyhound app to the driver when you board your bus from Wytheville to Cape Girardeau.
You can pay for your Greyhound bus ticket from Wytheville to Cape Girardeau by card, digital wallet, and other methods. All available payment options are shown at checkout. For more details, check our payments and tickets page.

Planning Your Greyhound Bus Trip from Wytheville to Cape Girardeau?

The journey from Wytheville to Cape Girardeau can take as little as 21 hours 50 minutes and starts from as little as $99.96. The earliest bus leaves at 02:15 am and the last bus leaves at 02:30 pm. Greyhound schedules 3 buses per day from Wytheville to Cape Girardeau. Travel with Greyhound and enjoy complimentary Wifi, access to power sockets, and a comfortable seat throughout your trip. Don't miss any updates on your bus trip: stay informed with our real-time bus tracker and check the status of your ride to Cape Girardeau in seconds.

How to Book Your Bus Ticket to Cape Girardeau from Wytheville

With Greyhound, reserving a ticket for your bus trip is a breeze. You can easily complete your booking on this website or through the free Greyhound App, all within a few simple clicks. You will have a variety of rides to choose from, as on many of our routes you will be offered both Greyhound and FlixBus bus rides, so you can choose the option that best fits your schedule. When booking your ticket from Wytheville to Cape Girardeau, you have a range of secure online payment options at your disposal, including both debit and credit cards. If you prefer, cash payments are also accepted at various sales points. If you're on the hunt for a cheap ticket to Cape Girardeau, remember to book early. Traveling on weekdays or during non-peak hours can also lead you to some of the most budget-friendly fares available!