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Bus from Winston-Salem, NC to San Antonio, TX

More travel options

You now can select from more schedules across U.S., Mexico and Canada with Greyhound and FlixBus.

Enjoy free onboard Wi-Fi

We offer free Wi-Fi and power outlets to keep you connected and powered up during your trip.

Reserve a Seat

Reserve your favorite seat when you book your ticket.

Need to make a change?

Easily change your ticket or add bags with Manage My Booking.

What to expect of your trip

Fast, easy, and affordable options from Winston-Salem, NC to San Antonio, TX

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Bus stations and stops in Winston-Salem, NC

Please note: your ticket will contain the most up-to-date address information.
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Available options you can find for a more comfortable trip:
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Free WiFi
Stay connected throughout your journey
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Power Outlets
Keep your devices charged on the go
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Comfortable seats
Relax with extra legroom and reclining seats
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Luggage storage
Space to safely stow your belongings
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Toilets
Conveniently available on every FlixBus
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Frequently asked questions

You can find the bus stops for Greyhound in both Winston-Salem and San Antonio by viewing the map on this page, which includes addresses and locations of all stops.
The Greyhound bus ride from Winston-Salem to San Antonio takes around 28 hours 55 minutes, covering a distance of approximately 1372 miles.
To track your Greyhound bus from Winston-Salem to San Antonio, use our bus tracker. It provides real-time updates on your bus’s location and expected arrival times.
For your trip from Winston-Salem to San Antonio, Greyhound allows one carry-on bag (up to 25 lbs, 16x12x7 inches) and one checked bag for free. If you have a Flexible fare, you can also check a second bag at no additional cost. Extra or oversized baggage can be added during booking or later via "Manage My Booking." Certain locations allow in-person payment for extra luggage. More details are available on our baggage policy page
Choosing Greyhound for your journey from Winston-Salem to San Antonio is an eco-conscious option, helping to reduce emissions and traffic compared to traveling by car.
Greyhound buses from Winston-Salem to San Antonio offer free Wi-Fi, power outlets at each seat, reclining seats with extra legroom, overhead storage, and onboard restrooms.
The first bus from Winston-Salem to San Antonio departs at 10:25 am.
The last bus from Winston-Salem to San Antonio departs at 6:15 pm.
Yes, you can book tickets for both Greyhound and FlixBus from Winston-Salem to San Antonio on our website. After entering your travel details, you can compare schedules and fares for both options.
There are up to 2 daily Greyhound bus trips from Winston-Salem to San Antonio. Use the search tool above to check the schedule.
Greyhound buses are equipped with wheelchair lifts and spaces for passengers using mobility devices. We recommend booking your trip from Winston-Salem to San Antonio in advance. Service animals are welcome on all Greyhound buses. For more information, please visit our accessibility page.

Plan your bus trip from Winston-Salem to San Antonio with Greyhound

The first bus departs at 10:25 am and the last bus departs at 6:15 pm. Greyhound operates 2 bus rides daily between Winston-Salem and San Antonio. When traveling with Greyhound to San Antonio from Winston-Salem, expect free Wifi, power sockets, and a guaranteed seat for your journey. Don't miss any updates on your bus trip: stay informed with our real-time bus tracker and check the status of your ride to San Antonio in seconds.

How to Book Your Bus Ticket to San Antonio from Winston-Salem

With Greyhound, reserving a ticket for your bus trip is a breeze. You can easily complete your booking on this website or through the free Greyhound App, all within a few simple clicks. You will have a variety of rides to choose from, as on many of our routes you will be offered both Greyhound and FlixBus bus rides, so you can choose the option that best fits your schedule. When booking your ticket from Winston-Salem to San Antonio, you have a range of secure online payment options at your disposal, including both debit and credit cards. If you prefer, cash payments are also accepted at various sales points. If you're on the hunt for a cheap ticket to San Antonio, remember to book early. Traveling on weekdays or during non-peak hours can also lead you to some of the most budget-friendly fares available!
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Onboard services are subject to availability