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Bus from St. Petersburg, FL to Des Moines, IA

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Bus stations and stops in St. Petersburg, FL

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Frequently asked questions

The first Greyhound bus from St. Petersburg to Des Moines departs at 12:01 am.
Onboard amenities on Greyhound buses from St. Petersburg to Des Moines include free Wi-Fi, personal power outlets, reclining seats with extra legroom, overhead storage, and an onboard restroom.
Opting for Greyhound to travel from St. Petersburg to Des Moines is an environmentally responsible choice, reducing traffic and lowering emissions compared to car travel.
When traveling from St. Petersburg to Des Moines with Greyhound, you can bring one carry-on bag (up to 25 lbs, 16x12x7 inches) for free. Additionally, one checked bag is included, with a second bag free for Flexible fare passengers. Extra or oversized baggage can be added during booking or later through the "Manage My Booking" section. Some locations also allow in-person payment for additional luggage. Full details are available on our baggage policy page.
To track your bus from St. Petersburg to Des Moines, use Greyhound’s bus tracker. This tool provides live updates on the bus’s location and expected arrival times.
Bus tickets from St. Petersburg to Des Moines start at $201.99. For the best rates, it is recommended to book in advance via our app or website. You can pay online using debit or credit cards, or choose to pay in person with cash at selected locations.
The journey by Greyhound bus from St. Petersburg to Des Moines covers approximately 1590 miles. The quickest trip duration is 35 hours 5 minutes, .
The last Greyhound bus from St. Petersburg to Des Moines leaves at 11:40 am.
You can find the Greyhound bus stops in both St. Petersburg and Des Moines by checking the map on this page, which shows the addresses and locations of all stops.
Greyhound buses are equipped with wheelchair lifts and have space for two passengers using wheelchairs or mobility scooters. We recommend booking your trip from St. Petersburg to Des Moines in advance to secure the necessary accommodations. Service animals are also welcome on all Greyhound buses. For more details, visit our accessibility page.
Greyhound operates up to 2 trips daily from St. Petersburg to Des Moines. You can find the schedule by entering your departure date in the search box above.
Yes, you can book both Greyhound and FlixBus tickets for travel from St. Petersburg to Des Moines through our website. After selecting your cities and travel dates, you can compare the schedules and prices of both services.

Onboard services are subject to availability