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Bus from St. Louis, MO to San Ysidro, CA

More travel options

You now can select from more schedules across U.S., Mexico and Canada with Greyhound and FlixBus.

Enjoy free onboard Wi-Fi

We offer free Wi-Fi and power outlets to keep you connected and powered up during your trip.

Reserve a Seat

Reserve your favorite seat when you book your ticket.

Need to make a change?

Easily change your ticket or add bags with Manage My Booking.

What to expect of your trip

Fast, easy, and affordable options from St Louis, MO to San Ysidro, CA

Avg. trip duration

42hr24mins

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Avg. distance

1966 miles

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Cheapest trip

From $229.97

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2

Avg. trips a day

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On this page

Bus stations and stops in St Louis, MO

Please note: your ticket will contain the most up-to-date address information.
Best service on board
Available options you can find for a more comfortable trip:
wifi
Free WiFi
Stay connected throughout your journey
socket
Power Outlets
Keep your devices charged on the go
seat
Comfortable seats
Relax with extra legroom and reclining seats
luggage
Luggage storage
Space to safely stow your belongings
toilet
Toilets
Conveniently available on every FlixBus
First time travelling with us?
More on our service
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Where to next?
Discover our travel map with over 1600 destinations across the U.S., Canada and Mexico.
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Frequently asked questions

You can find the bus stops for Greyhound in both St Louis and San Ysidro by viewing the map on this page, which includes addresses and locations of all stops.
The Greyhound bus ride from St Louis to San Ysidro takes around 41 hours, covering a distance of approximately 1924 miles.
To track your Greyhound bus from St Louis to San Ysidro, use our bus tracker. It provides real-time updates on your bus’s location and expected arrival times.
For your trip from St Louis to San Ysidro, Greyhound allows one carry-on bag (up to 25 lbs, 16x12x7 inches) and one checked bag for free. If you have a Flexible fare, you can also check a second bag at no additional cost. Extra or oversized baggage can be added during booking or later via "Manage My Booking." Certain locations allow in-person payment for extra luggage. More details are available on our baggage policy page
Choosing Greyhound for your journey from St Louis to San Ysidro is an eco-conscious option, helping to reduce emissions and traffic compared to traveling by car.
Greyhound buses from St Louis to San Ysidro offer free Wi-Fi, power outlets at each seat, reclining seats with extra legroom, overhead storage, and onboard restrooms.
The first bus from St Louis to San Ysidro departs at 1:20 am.
The last bus from St Louis to San Ysidro departs at 4:30 pm.
Yes, you can book tickets for both Greyhound and FlixBus from St Louis to San Ysidro on our website. After entering your travel details, you can compare schedules and fares for both options.
There are up to 2 daily Greyhound bus trips from St Louis to San Ysidro. Use the search tool above to check the schedule.
Greyhound buses are equipped with wheelchair lifts and spaces for passengers using mobility devices. We recommend booking your trip from St Louis to San Ysidro in advance. Service animals are welcome on all Greyhound buses. For more information, please visit our accessibility page.

Plan your bus trip from St Louis to San Ysidro with Greyhound

The first bus departs at 1:20 am and the last bus departs at 4:30 pm. Greyhound operates 2 bus rides daily between St Louis and San Ysidro. When traveling with Greyhound to San Ysidro from St Louis, expect free Wifi, power sockets, and a guaranteed seat for your journey. Don't miss any updates on your bus trip: stay informed with our real-time bus tracker and check the status of your ride to San Ysidro in seconds.

How to Book Your Bus Ticket to San Ysidro from St Louis

With Greyhound, reserving a ticket for your bus trip is a breeze. You can easily complete your booking on this website or through the free Greyhound App, all within a few simple clicks. You will have a variety of rides to choose from, as on many of our routes you will be offered both Greyhound and FlixBus bus rides, so you can choose the option that best fits your schedule. When booking your ticket from St Louis to San Ysidro, you have a range of secure online payment options at your disposal, including both debit and credit cards. If you prefer, cash payments are also accepted at various sales points. If you're on the hunt for a cheap ticket to San Ysidro, remember to book early. Traveling on weekdays or during non-peak hours can also lead you to some of the most budget-friendly fares available!

Onboard services are subject to availability