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Bus from St Louis, MO to Myrtle Beach, SC

More travel options

You now can select from more schedules across U.S., Mexico and Canada with Greyhound and FlixBus.

Enjoy free onboard Wi-Fi

We offer free Wi-Fi and power outlets to keep you connected and powered up during your trip.

Reserve a Seat

Reserve your favorite seat when you book your ticket.

Need to make a change?

Easily change your ticket or add bags with Manage My Booking.

What to expect of your trip

Fast, easy, and affordable options from St Louis, MO to Myrtle Beach, SC

Avg. trip duration

30hr50mins

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Avg. distance

1097 miles

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Cheapest trip

From $124.45

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1

Avg. trips a day

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On this page

Bus stations and stops in St Louis, MO

Please note: your ticket will contain the most up-to-date address information.
Best service on board
Available options you can find for a more comfortable trip:
wifi
Free WiFi
Stay connected throughout your journey
socket
Power Outlets
Keep your devices charged on the go
seat
Comfortable seats
Relax with extra legroom and reclining seats
luggage
Luggage storage
Space to safely stow your belongings
toilet
Toilets
Conveniently available on every FlixBus
First time travelling with us?
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Frequently asked questions

You can find the bus stops for Greyhound in both St Louis and Myrtle Beach by viewing the map on this page, which includes addresses and locations of all stops.
The Greyhound bus ride from St Louis to Myrtle Beach takes around 23 hours 50 minutes, covering a distance of approximately 1049 miles.
A bus ticket from St Louis to Myrtle Beach starts at $124.45. For the cheapest rates, it’s best to book in advance through our app or website. You can pay online with a debit or credit card, or in cash at select locations.
To track your Greyhound bus from St Louis to Myrtle Beach, use our bus tracker. It provides real-time updates on your bus’s location and expected arrival times.
For your trip from St Louis to Myrtle Beach, Greyhound allows one carry-on bag (up to 25 lbs, 16x12x7 inches) and one checked bag for free. If you have a Flexible fare, you can also check a second bag at no additional cost. Extra or oversized baggage can be added during booking or later via "Manage My Booking." Certain locations allow in-person payment for extra luggage. More details are available on our baggage policy page
Choosing Greyhound for your journey from St Louis to Myrtle Beach is an eco-conscious option, helping to reduce emissions and traffic compared to traveling by car.
Greyhound buses from St Louis to Myrtle Beach offer free Wi-Fi, power outlets at each seat, reclining seats with extra legroom, overhead storage, and onboard restrooms.
The first bus from St Louis to Myrtle Beach departs at 2:00 am.
The last bus from St Louis to Myrtle Beach departs at 4:00 pm.
Yes, you can book tickets for both Greyhound and FlixBus from St Louis to Myrtle Beach on our website. After entering your travel details, you can compare schedules and fares for both options.
There are up to one daily Greyhound bus trip from St Louis to Myrtle Beach. Use the search tool above to check the schedule.
Greyhound buses are equipped with wheelchair lifts and spaces for passengers using mobility devices. We recommend booking your trip from St Louis to Myrtle Beach in advance. Service animals are welcome on all Greyhound buses. For more information, please visit our accessibility page.

Looking for Greyhound Bus Tickets from St Louis to Myrtle Beach?

Your search ends here! We've got all the info you need to plan your bus journey. The trip from St Louis to Myrtle Beach can be as quick as 23 hours 50 minutes and as cost-effective as $124.45. The first bus of the day departs at 2:00 am and the last bus departs at 4:00 pm. Greyhound runs daily buses St Louis to Myrtle Beach between St Louis and Myrtle Beach. Traveling with Greyhound guarantees free Wifi, access to power sockets, and a guaranteed seat for your journey. Don't miss any updates on your bus trip: stay informed with our real-time bus tracker and check the status of your ride to Myrtle Beach in seconds.

How to Book Your Bus Trip to Myrtle Beach from St Louis

With Greyhound, reserving a ticket for your bus trip is a breeze. You can easily complete your booking on this website or through the free Greyhound App, all within a few simple clicks. You will have a variety of rides to choose from, as on many of our routes you will be offered both Greyhound and FlixBus bus rides, so you can choose the option that best fits your schedule. When booking your ticket from St Louis to Myrtle Beach, you have a range of secure online payment options at your disposal, including both debit and credit cards. If you prefer, cash payments are also accepted at various sales points. If you're on the hunt for a cheap ticket to Myrtle Beach, remember to book early. Traveling on weekdays or during non-peak hours can also lead you to some of the most budget-friendly fares available!

Onboard services are subject to availability