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Bus from Portland, OR to Greenville, SC

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Bus stations and stops in Portland, OR

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Frequently asked questions

The travel time from Portland to Greenville by bus is approximately 72 hours 20 minutes, covering a distance of about 3342 miles. The fastest route includes .
Bus tickets from Portland to Greenville start at $320.99. To get the best deals, book your tickets in advance through our app or website. Payment options include debit or credit cards online, or cash at certain locations.
You can check the status of your Greyhound bus traveling from Portland to Greenville by using our bus tracker. This tool provides real-time updates on your bus’s location and expected arrival time.
For your trip from Portland to Greenville, Greyhound allows one carry-on bag (max 25 lbs, 16x12x7 inches) and one checked bag under the bus at no extra charge. A second checked bag is free with a Flexible fare. You can add extra baggage during booking or later via "Manage My Booking," or at certain locations. Full details are on our baggage policy page.
Traveling by Greyhound from Portland to Greenville is an environmentally friendly option, helping to reduce carbon emissions and traffic congestion compared to car travel.
On Greyhound buses from Portland to Greenville, you can enjoy free Wi-Fi, power outlets at each seat, comfortable reclining seats with extra legroom, overhead storage, and access to an onboard restroom.
The earliest bus from Portland to Greenville departs at 7:15 am.
The latest bus from Portland to Greenville leaves at 7:25 pm.
Yes, you can book both Greyhound and FlixBus tickets for travel from Portland to Greenville on our website. Simply enter your travel details to compare schedules and fares.
There are up to one Greyhound bus operating daily from Portland to Greenville. Check the schedule by entering your travel date in the search box above.
Greyhound offers wheelchair lifts and space for passengers using mobility devices. It is recommended to book your trip from Portland to Greenville in advance. Service animals are welcome on all Greyhound buses. For more information, visit our accessibility page.
The locations of Greyhound bus stops in Portland and Greenville can be found on this page, along with detailed maps and addresses.

Planning Your Greyhound Bus Trip from Portland to Greenville?

The journey from Portland to Greenville can take as little as 72 hours 20 minutes and starts from as little as $320.99. The earliest bus leaves at 7:15 am and the last bus leaves at 7:25 pm. Greyhound provides daily buses Portland to Greenville from Portland to Greenville. Travel with Greyhound and enjoy complimentary Wifi, access to power sockets, and a comfortable seat throughout your trip. Don't miss any updates on your bus trip: stay informed with our real-time bus tracker and check the status of your ride to Greenville in seconds.

How to Book Your Bus Ticket to Greenville from Portland

With Greyhound, reserving a ticket for your bus trip is a breeze. You can easily complete your booking on this website or through the free Greyhound App, all within a few simple clicks. You will have a variety of rides to choose from, as on many of our routes you will be offered both Greyhound and FlixBus bus rides, so you can choose the option that best fits your schedule. When booking your ticket from Portland to Greenville, you have a range of secure online payment options at your disposal, including both debit and credit cards. If you prefer, cash payments are also accepted at various sales points. If you're on the hunt for a cheap ticket to Greenville, remember to book early. Traveling on weekdays or during non-peak hours can also lead you to some of the most budget-friendly fares available!

Onboard services are subject to availability