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Bus from Madisonville, KY to Greenville, SC

More travel options

You now can select from more schedules across U.S., Mexico and Canada with Greyhound and FlixBus.

Enjoy free onboard Wi-Fi

We offer free Wi-Fi and power outlets to keep you connected and powered up during your trip.

Reserve a Seat

Reserve your favorite seat when you book your ticket.

Need to make a change?

Easily change your ticket or add bags with Manage My Booking.

What to expect of your trip

Fast, easy, and affordable options from Madisonville, KY to Greenville, SC

Avg. trip duration

12 hr 39 mins

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Avg. distance

512 miles

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Cheapest trip

From $103.96

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2

Avg. trips a day

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Digital ticket & Live tracking

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Your tickets
Track your trip
Always in the know
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FlixBus app on phone

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Trusted by 500+ million passengers

On this page

Bus stations and stops in Madisonville, KY

Please note: your ticket will contain the most up-to-date address information.
Best service on board
Available options you can find for a more comfortable trip:
wifi
Free WiFi
Stay connected throughout your journey
socket
Power Outlets
Keep your devices charged on the go
seat
Comfortable seats
Relax with extra legroom and reclining seats
luggage
Luggage storage
Space to safely stow your belongings
toilet
Toilets
Conveniently available on every FlixBus
First time travelling with us?
More on our service
Amenities Hero Image

Onboard services are subject to availability

Where to next?
Discover our travel map with over 1600 destinations across the U.S., Canada and Mexico.
Explore the map
Vehicle passing through a city

Digital ticket & Live tracking

Discover the Greyhound app

Book trips
Your tickets
Track your trip
Always in the know
Get it on Google Play Download on the App Store
FlixBus app on phone

Scan to download the App

Trusted by 500+ million passengers

Frequently asked questions

Yes, you can book both Greyhound and FlixBus tickets for travel from Madisonville to Greenville on our website. Simply enter your travel details to compare schedules and fares.
The locations of Greyhound bus stops in Madisonville and Greenville can be found on this page, along with detailed maps and addresses.
Greyhound offers wheelchair lifts and space for passengers using mobility devices. It is recommended to book your trip from Madisonville to Greenville in advance. Service animals are welcome on all Greyhound buses. For more information, visit our accessibility page.
There are up to one Greyhound bus operating daily from Madisonville to Greenville. Check the schedule by entering your travel date in the search box above.
The latest bus from Madisonville to Greenville leaves at 06:50 pm.
The earliest bus from Madisonville to Greenville departs at 11:10 am.
On Greyhound buses from Madisonville to Greenville, you can enjoy free Wi-Fi, power outlets at each seat, comfortable reclining seats with extra legroom, overhead storage, and access to an onboard restroom.
Traveling by Greyhound from Madisonville to Greenville is an environmentally friendly option, helping to reduce carbon emissions and traffic congestion compared to car travel.
For your trip from Madisonville to Greenville, Greyhound allows one carry-on bag (max 25 lbs, 16x12x7 inches) and one checked bag under the bus at no extra charge. A second checked bag is free with a Flexible fare. You can add extra baggage during booking or later via "Manage My Booking," or at certain locations. Full details are on our baggage policy page.
You can check the status of your Greyhound bus traveling from Madisonville to Greenville by using our bus tracker. This tool provides real-time updates on your bus’s location and expected arrival time.
The travel time from Madisonville to Greenville by bus is approximately 12 hours 10 minutes, covering a distance of about 501 miles.

Planning Your Greyhound Bus Trip from Madisonville to Greenville?

How to Book Your Bus Ticket to Greenville from Madisonville

With Greyhound, reserving a ticket for your bus trip is a breeze. You can easily complete your booking on this website or through the free Greyhound App, all within a few simple clicks. You will have a variety of rides to choose from, as on many of our routes you will be offered both Greyhound and FlixBus bus rides, so you can choose the option that best fits your schedule. When booking your ticket from Madisonville to Greenville, you have a range of secure online payment options at your disposal, including both debit and credit cards. If you prefer, cash payments are also accepted at various sales points. If you're on the hunt for a cheap ticket to Greenville, remember to book early. Traveling on weekdays or during non-peak hours can also lead you to some of the most budget-friendly fares available!