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Bus from Lake City, FL to San Antonio, TX

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Bus stations and stops in Lake City, FL

Please note: your ticket will contain the most up-to-date address information.

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Frequently asked questions

The first Greyhound bus from Lake City to San Antonio departs at 9:40 am.
Onboard amenities on Greyhound buses from Lake City to San Antonio include free Wi-Fi, personal power outlets, reclining seats with extra legroom, overhead storage, and an onboard restroom.
Opting for Greyhound to travel from Lake City to San Antonio is an environmentally responsible choice, reducing traffic and lowering emissions compared to car travel.
When traveling from Lake City to San Antonio with Greyhound, you can bring one carry-on bag (up to 25 lbs, 16x12x7 inches) for free. Additionally, one checked bag is included, with a second bag free for Flexible fare passengers. Extra or oversized baggage can be added during booking or later through the "Manage My Booking" section. Some locations also allow in-person payment for additional luggage. Full details are available on our baggage policy page.
To track your bus from Lake City to San Antonio, use Greyhound’s bus tracker. This tool provides live updates on the bus’s location and expected arrival times.
The journey by Greyhound bus from Lake City to San Antonio covers approximately 1060 miles. The quickest trip duration is 21 hours 25 minutes, .
The last Greyhound bus from Lake City to San Antonio leaves at 7:20 pm.
You can find the Greyhound bus stops in both Lake City and San Antonio by checking the map on this page, which shows the addresses and locations of all stops.
Greyhound buses are equipped with wheelchair lifts and have space for two passengers using wheelchairs or mobility scooters. We recommend booking your trip from Lake City to San Antonio in advance to secure the necessary accommodations. Service animals are also welcome on all Greyhound buses. For more details, visit our accessibility page.
Greyhound operates up to 2 trips daily from Lake City to San Antonio. You can find the schedule by entering your departure date in the search box above.
Yes, you can book both Greyhound and FlixBus tickets for travel from Lake City to San Antonio through our website. After selecting your cities and travel dates, you can compare the schedules and prices of both services.

Planning Your Greyhound Bus Trip from Lake City to San Antonio?

How to Book Your Bus Ticket to San Antonio from Lake City

With Greyhound, reserving a ticket for your bus trip is a breeze. You can easily complete your booking on this website or through the free Greyhound App, all within a few simple clicks. You will have a variety of rides to choose from, as on many of our routes you will be offered both Greyhound and FlixBus bus rides, so you can choose the option that best fits your schedule. When booking your ticket from Lake City to San Antonio, you have a range of secure online payment options at your disposal, including both debit and credit cards. If you prefer, cash payments are also accepted at various sales points. If you're on the hunt for a cheap ticket to San Antonio, remember to book early. Traveling on weekdays or during non-peak hours can also lead you to some of the most budget-friendly fares available!

Onboard services are subject to availability