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Bus from Greenville, SC to St Louis, MO

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Bus stations and stops in Greenville, SC

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Frequently asked questions

The first Greyhound bus from Greenville to St Louis departs at 3:30 pm.
Onboard amenities on Greyhound buses from Greenville to St Louis include free Wi-Fi, personal power outlets, reclining seats with extra legroom, overhead storage, and an onboard restroom.
Opting for Greyhound to travel from Greenville to St Louis is an environmentally responsible choice, reducing traffic and lowering emissions compared to car travel.
When traveling from Greenville to St Louis with Greyhound, you can bring one carry-on bag (up to 25 lbs, 16x12x7 inches) for free. Additionally, one checked bag is included, with a second bag free for Flexible fare passengers. Extra or oversized baggage can be added during booking or later through the "Manage My Booking" section. Some locations also allow in-person payment for additional luggage. Full details are available on our baggage policy page.
To track your bus from Greenville to St Louis, use Greyhound’s bus tracker. This tool provides live updates on the bus’s location and expected arrival times.
Bus tickets from Greenville to St Louis start at $174.99. For the best rates, it is recommended to book in advance via our app or website. You can pay online using debit or credit cards, or choose to pay in person with cash at selected locations.
The journey by Greyhound bus from Greenville to St Louis covers approximately 713 miles. The quickest trip duration is 15 hours 5 minutes, .
The last Greyhound bus from Greenville to St Louis leaves at 7:45 pm.
You can find the Greyhound bus stops in both Greenville and St Louis by checking the map on this page, which shows the addresses and locations of all stops.
Greyhound buses are equipped with wheelchair lifts and have space for two passengers using wheelchairs or mobility scooters. We recommend booking your trip from Greenville to St Louis in advance to secure the necessary accommodations. Service animals are also welcome on all Greyhound buses. For more details, visit our accessibility page.
Greyhound operates up to 2 trips daily from Greenville to St Louis. You can find the schedule by entering your departure date in the search box above.
Yes, you can book both Greyhound and FlixBus tickets for travel from Greenville to St Louis through our website. After selecting your cities and travel dates, you can compare the schedules and prices of both services.

Plan your bus trip from Greenville to St Louis with Greyhound

The trip from Greenville to St Louis takes as short as 15 hours 5 minutes and could cost as little as $174.99. The first bus departs at 3:30 pm and the last bus departs at 7:45 pm. Greyhound operates 2 bus rides daily between Greenville and St Louis. When traveling with Greyhound to St Louis from Greenville, expect free Wifi, power sockets, and a guaranteed seat for your journey. Don't miss any updates on your bus trip: stay informed with our real-time bus tracker and check the status of your ride to St Louis in seconds.

How to Book Your Bus Ticket to St Louis from Greenville

With Greyhound, reserving a ticket for your bus trip is a breeze. You can easily complete your booking on this website or through the free Greyhound App, all within a few simple clicks. You will have a variety of rides to choose from, as on many of our routes you will be offered both Greyhound and FlixBus bus rides, so you can choose the option that best fits your schedule. When booking your ticket from Greenville to St Louis, you have a range of secure online payment options at your disposal, including both debit and credit cards. If you prefer, cash payments are also accepted at various sales points. If you're on the hunt for a cheap ticket to St Louis, remember to book early. Traveling on weekdays or during non-peak hours can also lead you to some of the most budget-friendly fares available!

Onboard services are subject to availability