Bus from Fort Myers, FL to Frederick, MD
More travel options
You now can select from more schedules across U.S., Mexico and Canada with Greyhound and FlixBus.
Enjoy free onboard Wi-Fi
We offer free Wi-Fi and power outlets to keep you connected and powered up during your trip.
Reserve a Seat
Reserve your favorite seat when you book your ticket.
Need to make a change?
Easily change your ticket or add bags with Manage My Booking.
What to expect of your trip
Fast, easy, and affordable options from Fort Myers, FL to Frederick, MD
Avg. trip duration
36 hr 10 mins
Avg. distance
1433 miles
Cheapest trip
From $253.93
1
Avg. trips a day
On this page
Bus stations and stops in Fort Myers, FL
Fort Myers Bus Stop
2250 Widman Way
Fort Myers, FL 33901
United States
Fort Myers, FL 33901
United States
Effective 8/27/2025, bus boards from the Rosa Parks Transportation Center at 2250 Widman Way. Bus WILL NOT stop at the Edison Mall.
Bus will board from the Rosa Parks Transportation Center at 2250 Widman Way. Bus will not stop at the McDonalds on Daniels Pkwy.
To view more info about this station, visit our page Fort Myers Bus Stop
Best service on board
Available options you can find for a more comfortable trip:
Free WiFi
Stay connected throughout your journey
Power Outlets
Keep your devices charged on the go
Comfortable seats
Relax with extra legroom and reclining seats
Luggage storage
Space to safely stow your belongings
Toilets
Conveniently available on every FlixBus
First time travelling with us?
More on our service
Frequently asked questions
How much is the Fort Myers to Frederick bus and how can I buy a ticket?
Can I book bus tickets both for Greyhound and FlixBus to travel from Fort Myers to Frederick?
How long does the bus from Fort Myers to Frederick take with Greyhound?
How many daily Greyhound bus trips are there from Fort Myers to Frederick?
How do I track my Greyhound bus from Fort Myers to Frederick ?
What onboard services are available on Greyhound buses from Fort Myers to Frederick?
What time is the first bus from Fort Myers to Frederick?
What time is the last bus from Fort Myers to Frederick?
How much baggage can I bring on the bus from Fort Myers to Frederick?
What facilities does Greyhound provide for passengers with reduced mobility and service animals?
Is traveling with Greyhound from Fort Myers to Frederick environmentally-friendly?
Where are the Greyhound bus stops in Fort Myers and in Frederick?
- Fort Myers has 1 bus stop(s), namely: Fort Myers Bus Stop
- Frederick has 2 bus stop(s), namely: Frederick Airport, Frederick Bus Station
Plan your bus trip from Fort Myers to Frederick with Greyhound
The trip from Fort Myers to Frederick takes as short as 36 hours 10 minutes and could cost as little as $253.93. The first bus departs at 6:30 pm. Greyhound offers daily bus rides from Fort Myers to Frederick. When traveling with Greyhound to Frederick from Fort Myers, expect free Wifi, power sockets, and a guaranteed seat for your journey. Don't miss any updates on your bus trip: stay informed with our real-time bus tracker and check the status of your ride to Frederick in seconds.How to Book Your Bus Ticket to Frederick from Fort Myers
With Greyhound, reserving a ticket for your bus trip is a breeze. You can easily complete your booking on this website or through the free Greyhound App, all within a few simple clicks. You will have a variety of rides to choose from, as on many of our routes you will be offered both Greyhound and FlixBus bus rides, so you can choose the option that best fits your schedule. When booking your ticket from Fort Myers to Frederick, you have a range of secure online payment options at your disposal, including both debit and credit cards. If you prefer, cash payments are also accepted at various sales points. If you're on the hunt for a cheap ticket to Frederick, remember to book early. Traveling on weekdays or during non-peak hours can also lead you to some of the most budget-friendly fares available!Discover more popular bus connections
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Onboard services are subject to availability