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Bus from Boston, MA to San Ysidro, CA
More travel options
You now can select from more schedules across U.S., Mexico and Canada with Greyhound and FlixBus.
Enjoy free onboard Wi-Fi
We offer free Wi-Fi and power outlets to keep you connected and powered up during your trip.
Reserve a Seat
Reserve your favorite seat when you book your ticket.
Need to make a change?
Easily change your ticket or add bags with Manage My Booking.
What to expect of your trip
Fast, easy, and affordable options from Boston, MA to San Ysidro, CA
Digital ticket & Live tracking
Bus stations and stops in Boston, MA
Boston (South Station)
700 Atlantic Ave
Boston, MA 02111
United States
Boston, MA 02111
United States
View this address on Google Maps
Greyhound and FlixBus buses will arrive and depart from the South Wing and departure gate numbers will be Gates #13, #14, and #18-27.
To view more info about this station, visit our page Boston (South Station)
Brookline
278 Harvard St
Boston, MA 02446
United States
Boston, MA 02446
United States
View this address on Google Maps
Please wait near the MBTA 66 Bus stop curbside on Harvard Street near Coolidge Corner Opticians. Do not block the entrance to Coolidge Corner Opticians or any other nearby stores.
To view more info about this station, visit our page Brookline
Cambridge (MA)
151 Steel Place
Boston, MA 02140
United States
Boston, MA 02140
United States
View this address on Google Maps
From Alewife MBTA station, follow signs towards Cambridgepark Dr. Go up the ramp towards Cambridgepark Dr and Ringe Ave. Cross Cambridgepark Dr. Bus will stop in circle on Steel Place next to Summer Shack restaurant parking lot.
To view more info about this station, visit our page Cambridge (MA)
Best service on board
Available options you can find for a more comfortable trip:
Free WiFi
Stay connected throughout your journey
Power Outlets
Keep your devices charged on the go
Comfortable seats
Relax with extra legroom and reclining seats
Luggage storage
Space to safely stow your belongings
Toilets
Conveniently available on every FlixBus
First time travelling with us?
More on our service
Onboard services are subject to availability
Digital ticket & Live tracking
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